Endocrine Abstracts

Background: Pathological accumulation of intrahepatocellular triglyceride (IHTG) is the first stage non-alcoholic fatty liver disease (NAFLD), which encompasses a spectrum of disease from simple steatosis through to cirrhosis. Dietary interventions have demonstrated alterations in dietary fat quantity and quality affect IHTG content; diets rich in saturated compared to unsaturated fat increase IHTG accumulation to a greater extent. Studying the underlying mechanisms in viv...

Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases starting with pathological accumulation of intrahepatocellular triglyceride (TG) (i.e. steatosis), which can progress to steatohepatitis (NASH) and cirrhosis. Insulin resistance is often associated with the development of steatosis and disease progression however, the underlying mechanisms for this are poorly defined. A major challenge in modelling human NAFLD disease progression is the la...